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Anti-Human Serpin A1/alpha 1-Antitrypsin Reference Antibody (Efdoralprin Alfa, RUO) (HF638026)

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概述
货号HF638026
品牌abinScience
描述
efdoralprin alfa (HF638026) is a research-grade recombinant antibody targeting Bone marrow serine protease.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
种属反应性Human
应用ELISA, Functional assay, Research in vivo
克隆类型Monoclonal
种属Human
靶标Bone marrow serine protease, EC:3.4.21.37, ELA2, ELANE, Elastase-2, HLE, Human leukocyte elastase, Medullasin, Neutrophil elastase, PMN elastase
内毒素水平< 10 EU/mg
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P08246
状态Liquid
保存溶液 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名CAS: 2539844-42-1
背景

Neutrophil elastase (AAT) is a ~28 kDa protein. Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG).

1. Tralau, T. et al. (2004) Experimental dermatology 13, 316-25. PMID: 15140022
2. Oltra, SS. et al. (2023) Cell death and differentiation 30, 1366-1381. PMID: 36899106
3. Massberg, S. et al. (2010) Nature medicine 16, 887-96. PMID: 20676107
4. Waisberg, M. et al. (2014) PLoS pathogens 10, e1004338. PMID: 25211214
5. Si-Tahar, M. et al. (1997) The Journal of biological chemistry 272, 11636-47. PMID: 9111081
6. Belaaouaj, A. et al. (2000) Science (New York, N.Y.) 289, 1185-8. PMID: 10947984
NoteFor research use only. Not suitable for clinical or therapeutic use.
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参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human Serpin A1/alpha 1-Antitrypsin Reference Antibody (Efdoralprin Alfa, RUO)

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