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Anti-Human PACAP/ADCYAP1 Reference Antibody (Bocunebart, RUO) (HB716046)

价格:
规格:
  • 100ug
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
数量:
  • 概述

  • 图片

  • 参考文献

  • 产品说明书

概述
货号HB716046
品牌abinScience
描述
bocunebart (HB716046) is a research-grade recombinant antibody targeting PACAP/ADCYAP1.
Highlights
  • Research Grade — For PK/PD studies, assay development, and ADA research.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主Human
同种型IgG1, Kappa
种属Human
克隆类型Monoclonal
靶标PACAP/ADCYAP1
内毒素水平< 10 EU/mg
纯度>95% as determined by SDS-PAGE.
Accession号P18509
状态Liquid
重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名2984605-64-1
背景

Pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.

1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907
2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469
3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270
4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
NoteFor research use only. Not suitable for clinical or therapeutic use.
图片
  • SDS-PAGE

    SDS-PAGE for Research Grade bocunebart

参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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