

| 货号 | HB716046 |
|---|---|
| 品牌 | abinScience |
| 描述 |
bocunebart (HB716046) is a research-grade recombinant antibody targeting PACAP/ADCYAP1.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1, Kappa |
| 种属 | Human |
| 克隆类型 | Monoclonal |
| 靶标 | PACAP/ADCYAP1 |
| 内毒素水平 | < 10 EU/mg |
| 纯度 | >95% as determined by SDS-PAGE. |
| Accession号 | P18509 |
| 状态 | Liquid |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | 2984605-64-1 |
| 背景 | Pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. 1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907 2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469 3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for Research Grade bocunebart



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