Anti-Human PD-1 Reference Antibody (Abazistobart, RUO) (HS870576)

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概述
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概述

货号	HS870576
品牌	abinScience
描述	abazistobart (HS870576) is a research-grade recombinant antibody targeting CD279. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG4, Kappa
种属	Human
克隆类型	Monoclonal
靶标	CD279/PDCD1/PD1
内毒素水平	< 10 EU/mg
纯度	>95% as determined by SDS-PAGE.
Accession号	Q15116
状态	Liquid
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	3002062-67-8
背景	Programmed cell death protein 1 (CD279/PDCD1) is a ~31 kDa protein. Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. 1. Fife, BT. et al. (2011) Annals of the New York Academy of Sciences 1217, 45-59. PMID: 21276005 2. Bardhan, K. et al. (2019) Scientific reports 9, 17252. PMID: 31754127 3. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441 4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329 5. Zak, KM. et al. (2015) Structure (London, England : 1993) 23, 2341-2348. PMID: 26602187
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade abazistobart

参考文献

产品说明书

Anti-Human PD-1 Reference Antibody (Abazistobart, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PD-1 Reference Antibody (Abazistobart, RUO) (HS870576)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PD-1 Reference Antibody (Abazistobart, RUO) (HS870576)

概述

图片

参考文献

产品说明书

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