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Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO) (HP769016)

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概述
货号HP769016
品牌abinScience
描述
Serrumab (HP769016) is a research-grade recombinant antibody targeting Tityustoxin VIIToxin VIITs7. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Tityus serrulatus (Brazilian scorpion)
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主Human
同种型IgG1, kappa
表达系统Mammalian cells
克隆类型Monoclonal
靶标Tityustoxin VIIToxin VIITs7
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P15226
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Beta-mammal/insect toxin Ts1 (Tityustoxin VIIToxin VIITs7) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1).

1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296
2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594
3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548
4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450
5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206
6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
NoteFor research use only. Not suitable for clinical or therapeutic use.
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Serrumab.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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