

| 货号 | HT065016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG1-kappa |
| 克隆号 | BIIB023 |
| 表达系统 | Mammalian cells |
| 克隆类型 | Monoclonal |
| 靶标 | TWEAK, DR3LG, TNFSF12, Tumor necrosis factor ligand superfamily member 12, APO3L, TNF-related weak inducer of apoptosis, APO3 ligand |
| 内毒素水平 | < 10 EU/mg |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | O43508 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | BIIB023, DHK29401 |
| 背景 | Tumor necrosis factor ligand superfamily member 12 (CD255/TNFSF12) is a ~27 kDa protein. Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. |
| 文献 | 1. Galluppi GR, et al. Population pharmacokinetic and pharmacodynamic analysis of BIIB023, an anti-TNF-like weak inducer of apoptosis (anti-TWEAK) monoclonal antibody. Br J Clin Pharmacol. 2016 Jul;82(1):118-28. [HT065016] |
| Note | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for Research Grade Anti-Human TWEAK/TNFSF12 (BIIB023)



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