Research Grade Gulgafafusp Alfa (HW328026)

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货号	HW328026
品牌	abinScience
种属反应性	Human
应用	ELISA, Functional assay, Research in vivo
克隆类型	Monoclonal
同种型	human glucagonlike peptide 1 receptor, GLP1R fused at the N-terminus of each light chain (53-266) via the peptide linker 30GSGSATGGSGSGASSGSGSATGS52 to a glucagon-like peptide-1 (GLP-1) fragment
生物活性	GLP-1 (7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats [2]. Infusion of GLP-1 (7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM [2].
表达系统	Mammalian cells
靶标	GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R, GLP-1(7-36), Incretin hormone, GLP-2, GCG, GLP-1(7-37), OXM, Pro-glucagon, GLP-1, GRPP, OXY
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Purified by Nickel column.
Accession号	P43220 & P01275
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	2642374-02-3
背景	Gulgafafusp alfa is a human IgG2κ antibody targeting the glucagon-like peptide 1 receptor GLP1R.
文献	1. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). [HW328026] 2. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7. [HW328026]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Gulgafafusp Alfa.

产品说明书

Research Grade Gulgafafusp Alfa.pdf

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Research Grade Gulgafafusp Alfa (HW328026)

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Research Grade Gulgafafusp Alfa (HW328026)

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