Anti-Human PABPC1 Reference Antibody (Alextatug, RUO) (HY439016)

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概述

货号	HY439016
品牌	abinScience
描述	Alextatug (HY439016) is a research-grade recombinant antibody targeting PABP-1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
克隆类型	Monoclonal
同种型	IgG1-lambda
表达系统	Mammalian cells
靶标	PABP-1, PAB1, PABPC2, PABPC1, Polyadenylate-binding protein 1, Poly(A)-binding protein 1, PABP1
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P11940
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	2768264-93-1
背景	Polyadenylate-binding protein 1 (PABPC1) is a ~70 kDa protein. Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. 1. Grosset, C. et al. (2000) Cell 103, 29-40. PMID: 11051545 2. Patel, GP. et al. (2006) The FEBS journal 273, 5678-90. PMID: 17212783 3. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299 4. Schäffler, K. et al. (2010) RNA (New York, N.Y.) 16, 1488-99. PMID: 20573744 5. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947 6. Singh, G. et al. (2008) PLoS biology 6, e111. PMID: 18447585
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

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SDS-PAGE

SDS-PAGE for Research Grade Alextatug.

参考文献

产品说明书

Anti-Human PABPC1 Reference Antibody (Alextatug, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PABPC1 Reference Antibody (Alextatug, RUO) (HY439016)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PABPC1 Reference Antibody (Alextatug, RUO) (HY439016)

概述

图片

参考文献

产品说明书

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