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Anti-Human CD19 Reference Antibody (Immunomedics hA19, RUO) (HB996336)

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概述
货号HB996336
品牌abinScience
描述
Anti-Human CD19 Antibody (Immunomedics hA19) (HB996336) is a research-grade recombinant antibody targeting CD19. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主Human
同种型IgG
克隆号Immunomedics hA19
表达系统Mammalian cells
靶标CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P15391
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

B-lymphocyte antigen CD19 is a ~61 kDa protein. Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. CD19 is the therapeutic target of tafasitamab (Monjuvi).

1. Vanshylla, K. et al. (2018) Scientific reports 8, 4244. PMID: 29523808
2. Carter, RH. et al. (1992) Science (New York, N.Y.) 256, 105-7. PMID: 1373518
3. van Zelm, MC. et al. (2006) The New England journal of medicine 354, 1901-12. PMID: 16672701
4. de Rie, MA. et al. (1989) Cellular immunology 118, 368-81. PMID: 2463100
5. Wang, Y. et al. (2002) Immunity 17, 501-14. PMID: 12387743
6. Sato, S. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 3278-87. PMID: 9317126
7. Buhl, AM. et al. (1997) The Journal of experimental medicine 186, 1897-910. PMID: 9382888
NoteFor research use only. Not suitable for clinical or therapeutic use.
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Anti-Human CD19 Antibody (Immunomedics hA19)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CD19 Reference Antibody (Immunomedics hA19, RUO)

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