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Anti-Human HAMP/Hepcidin Reference Antibody (Ludwig-Maximilians U. anti_Hepsin, RUO) (HX911036)

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概述
货号HX911036
品牌abinScience
描述
Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin) (HX911036) is a research-grade recombinant antibody targeting Putative liver tumor regressor. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主Human
同种型IgG
克隆号Ludwig-Maximilians U. anti_Hepsin
表达系统Mammalian cells
靶标Putative liver tumor regressor, HEPC, LEAP-1, Liver-expressed antimicrobial peptide 1, PLTR, Hepcidin, LEAP1, Hepc25, Hepc20, HAMP
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P81172
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.

1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227
2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594
3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342
4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005
NoteFor research use only. Not suitable for clinical or therapeutic use.
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human HAMP/Hepcidin Reference Antibody (Ludwig-Maximilians U. anti_Hepsin, RUO)

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