Anti-Human CD93/C1qR Antibody (Dcby02) (HV345016) is a research-grade recombinant antibody targeting CD93. Produced in mammalian cells with native-like glycosylation.
Highlights
●Research Grade — For PK/PD studies, assay development, and ADA research.
Protein A/G purified from cell culture supernatant.
Accession号
Q9NPY3
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
Dcby02, Dcby02, Dcby-02
背景
Complement component C1q receptor (CD93/C1qR) is a ~68 kDa protein. Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration.
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3. Galvagni, F. et al. (2016) Oncotarget 7, 10090-103. PMID: 26848865
4. Khan, KA. et al. (2017) Oncogene 36, 6097-6108. PMID: 28671670
5. Barbera, S. et al. (2023) International journal of biological macromolecules 224, 453-464. PMID: 36265539
6. Xu, Y. et al. (2024) Structure (London, England : 1993) 32, 282-291.e4. PMID: 38218180
Note
For research use only. Not suitable for clinical or therapeutic use.
图片
SDS-PAGE
SDS-PAGE for Research Grade Anti-Human CD93/C1qR Antibody (Dcby02)
