| 背景 | Interleukin-20 (IL20,Cytokine Zcyto10,ZCYTO10,IL-20,Interleukin-20) is a ~20 kDa protein. Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation. Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB. 1. Sa, SM. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 2229-40. PMID: 172771283. Gough, P. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 198, 4373-4382. PMID: 284242384. Wang, M. et al. (2002) The Journal of biological chemistry 277, 7341-7. PMID: 117060205. Dumoutier, L. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 3545-9. PMID: 115647636. Andrés, RM. et al. (2013) Experimental dermatology 22, 323-8. PMID: 23614738 |
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