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Anti-Human CCR8 Reference Antibody (Tagmokitug, RUO) (HW444066)

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概述
货号HW444066
品牌abinScience
描述
tagmokitug (HW444066) is a research-grade recombinant antibody targeting CD198.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
种属反应性Human
应用ELISA, FACS, Functional assay
宿主Human
同种型IgG1, lambda2
克隆类型Monoclonal
靶标CD198/CCR8
内毒素水平< 10 EU/mg
纯度>95% as determined by SDS-PAGE
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P51685
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名CAS: 3024486-14-1
背景

C-C chemokine receptor type 8 is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage.

1. Islam, SA. et al. (2013) The Journal of experimental medicine 210, 1889-98. PMID: 23999500
2. Ding, D. et al. (2022) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 42, 19-28. PMID: 35041514
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade tagmokitug

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CCR8 Reference Antibody (Tagmokitug, RUO)

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