| 货号 | HV243016 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主 | Human |
| 同种型 | IgG2-lambda |
| 表达系统 | Mammalian Cells |
| 种属 | Human |
| 克隆类型 | Monoclonal |
| 靶标 | TSLP, Thymic stromal lymphopoietin |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q969D9 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 别名 | AMG 157, AMG-157, MEDI-9929, MEDI9929, anti-TSLP-Receptor (TSLP-R, Crl2), 1572943-04-4 |
| 背景 | Tezepelumab is a first-in-class human monoclonal antibody that binds to TSLP, thus inhibiting its interaction with TSLP receptor complex. Tezepelumab given as an add-on-therapy to patients with severe uncontrolled asthma has shown safety, tolerability and efficacy. Several trials are evaluating the long-term safety and the efficacy of tezepelumab in adults and adolescents with severe uncontrolled asthma. • Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma., PMID:37628907 • Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma., PMID:32567399 • Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD., PMID:36697211 • Role of thymic stromal lymphopoietin in allergy and beyond., PMID:35650271 • IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin., PMID:36410530 • Serum thymic stromal lymphopoietin (TSLP) levels in atopic dermatitis patients: a systematic review and meta-analysis., PMID:37515689 • Thymic Stromal Lymphopoietin and Tezepelumab in Airway Diseases: From Physiological Role to Target Therapy., PMID:38892164 • Investigational thymic stromal lymphopoietin inhibitors for the treatment of asthma: a systematic review., PMID:38206116 • Pathogenesis of allergic diseases and implications for therapeutic interventions., PMID:36964157 • Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis., PMID:37500310 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Detects TSLP in indirect ELISAs.
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