Research Grade Tebentafusp (HY057066) is a humanized monoclonal antibody detecting CD3E in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
●Multi-Application — Validated across multiple applications.
种属反应性
Human
应用
ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
产品使用信息
应用方法
稀释比例
ELISA
1:2000-1:20000
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
Bispecific fusion protein, 1874157-95-5
背景
T-cell surface glycoprotein CD3 epsilon chain (CD3E,gp100 peptide-HLA Complex,T3E,T-cell surface antigen T3/Leu-4 epsilon chain,T-cell surface glycoprotein CD3 epsilon chain) is a ~23 kDa protein. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3E ITAM phosphorylation creates docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme.
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Note
For research use only. Not suitable for clinical or therapeutic use.
