| 背景 | Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein,CD14,Monocyte differentiation antigen CD14) is a ~40 kDa protein. Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). 1. Wright, SD. et al. (1990) Science (New York, N.Y.) 249, 1431-3. PMID: 16983112. Kelley, SL. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1304-11. PMID: 232646553. Tsukamoto, H. et al. (2010) International immunology 22, 271-80. PMID: 201334934. Murakami, K. et al. (2012) FEBS letters 586, 319-24. PMID: 222656926. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 168802117. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187 |
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