Integrin beta-2 (Complement receptor C3 subunit beta,Cell surface adhesion glycoproteins LFA-1/CR3) is a ~84 kDa protein. Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. 1. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 16760482. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 237755903. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 381956294. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 291000555. Van der Vieren, M. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1984-90. PMID: 104389356. Van der Vieren, M. et al. (1995) Immunity 3, 683-90. PMID: 87777147. Grayson, MH. et al. (1998) The Journal of experimental medicine 188, 2187-91. PMID: 98419328. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 153561109. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992 | 
