Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO) (HT348156)

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概述
图片
参考文献
产品说明书

概述

货号

HT348156

品牌

abinScience

描述

Zaptuzumab (HT348156) is a research-grade recombinant antibody targeting CD262.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

种属反应性

Human

应用

ELISA, FACS, Functional assay

宿主

Human

克隆类型

Monoclonal

靶标

CD262, DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9

内毒素水平

< 10 EU/mg

纯度

>95% as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

O14763

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tumor necrosis factor receptor superfamily member 10B (DR5) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO) (HT348156)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO) (HT348156)

概述

图片

参考文献

产品说明书

相关产品推荐

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