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Anti-Human ICAM-1/CD54 Reference Antibody (Bersanlimab, RUO) (HY321016)

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概述
货号HY321016
品牌abinScience
描述
Bersanlimab (HY321016) is a research-grade recombinant antibody targeting CD54. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-lambda
表达系统Mammalian cells
靶标ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P05362
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名BI-505, 1987854-08-9
背景

Intercellular adhesion molecule 1 (CD54/ICAM1) is a ~57 kDa protein. Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1.

1. Dustin, ML. et al. (1986) Journal of immunology (Baltimore, Md. : 1950) 137, 245-54. PMID: 3086451
2. Simmons, D. et al. (1988) Nature 331, 624-7. PMID: 3340213
3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629
4. Diamond, MS. et al. (1990) The Journal of cell biology 111, 3129-39. PMID: 1980124
5. van Buul, JD. et al. (2007) The Journal of cell biology 178, 1279-93. PMID: 17875742
6. Hayashi, T. et al. (2001) Digestion 63 Suppl 1, 87-92. PMID: 11173916
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlAnti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)
图片

  • Bioactivity

    Detects CD54/ICAM1 in indirect ELISAs.

  • SDS-PAGE

    SDS-PAGE for Research Grade Bersanlimab.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human ICAM-1/CD54 Reference Antibody (Bersanlimab, RUO)

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