Anti-Human IL-3R alpha/CD123 Reference Antibody (Talacotuzumab, RUO) (HB714016)

价格:

规格：

100ug
1mg
5mg
10mg
25mg
50mg
100mg

数量：

联系我们

一键复制产品信息

概述
图片
参考文献
产品说明书

概述

货号	HB714016
品牌	abinScience
描述	Talacotuzumab (HB714016) is a research-grade recombinant antibody targeting CD123. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa
表达系统	Mammalian cells
经测试应用	WB
靶标	IL-3R subunit alpha, IL-3 receptor subunit alpha, CD123, Interleukin-3 receptor subunit alpha, IL3R, IL-3R-alpha, IL3RA, IL-3RA
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P26951
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	CSL-362-AML, CSL362, JNJ-56022473, 1826831-79-1
背景	Interleukin-3 receptor subunit alpha (CD123/IL-3Rα) is a ~43 kDa protein. Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. 1. Huang, S. et al. (1999) Stem cells (Dayton, Ohio) 17, 265-72. PMID: 10527461
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

图片

Bioactivity

Detects CD123/IL3RA in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Talacotuzumab.
Western blot

Western blot analysis was performed using anti-CD123/IL3RA monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human CD123/IL3RA (Catalog No: HB714011), 50ng
Lane 2: recombinant human CD123/IL3RA (Catalog No: HB714011), 30ng
Lane 3: recombinant human CD123/IL3RA (Catalog No: HB714011), 20ng

参考文献

产品说明书

Anti-Human IL-3R alpha/CD123 Reference Antibody (Talacotuzumab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IL-3R alpha/CD123 Reference Antibody (Talacotuzumab, RUO) (HB714016)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IL-3R alpha/CD123 Reference Antibody (Talacotuzumab, RUO) (HB714016)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价