Recombinant Human CD338/ABCG2 Protein, N-His (PX-P5616)
概述
图片
参考文献
概述
货号
PX-P5616
品牌
ProteoGenix
描述
Recombinant Human CD338/ABCG2 Protein, N-His (PX-P5616) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
E. coli Expression — Optimized for functional studies.
表达系统
E. coli
Accession号
Q9UNQ0
蛋白长度
Asn557-His630
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
10.72 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
Urate exporter, ABCP, BCRP1, ABCG2, CD338, BCRP, MXR, Broad substrate specificity ATP-binding cassette transporter ABCG2, Placenta-specific ATP-binding cassette transporter, Breast cancer resistance protein, Mitoxantrone resistance-associated protein, CDw338, ATP-binding cassette sub-family G member 2
背景
Broad substrate specificity ATP-binding cassette transporter ABCG2 (CD338) is a ~72 kDa protein. Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate.
1. Komatani, H. et al. (2001) Cancer research 61, 2827-32. PMID: 11306452
2. Zhang, W. et al. (2003) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 2085-7. PMID: 12958161
3. Woodward, OM. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 10338-42. PMID: 19506252
4. Desuzinges-Mandon, E. et al. (2010) The Journal of biological chemistry 285, 33123-33133. PMID: 20705604
