Recombinant Human CD159c/KLRC2 Protein, C-His (PX-P6372)
概述
图片
参考文献
概述
货号
PX-P6372
品牌
ProteoGenix
描述
Recombinant Human CD159c/KLRC2 Protein, C-His (PX-P6372) expressed in Mammalian Cells, Purity: >90% as determined by SDS-PAGE..
Highlights
High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
Mammalian Cells Expression — Optimized for functional studies.
表达系统
Mammalian Cells
Accession号
P26717
蛋白长度
Glu98-Leu231
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
18.50 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
NKG2-C type II integral membrane protein, CD159 antigen-like family member C, NK cell receptor C, NKG2-C-activating NK receptor, CD159c, KLRC2, NKG2C
背景
NKG2-C type II integral membrane protein (CD159c/KLRC2) is a ~26 kDa protein. Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
1. Rölle, A. et al. (2018) Cell reports 24, 1967-1976.e4. PMID: 30134159
2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229
3. Llano, M. et al. (1998) European journal of immunology 28, 2854-63. PMID: 9754572
4. Angelini, DF. et al. (2011) Journal of leukocyte biology 89, 75-84. PMID: 20952657
5. Lopez-Vergès, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 14725-32. PMID: 21825173
6. Gumá, M. et al. (2005) European journal of immunology 35, 2071-80. PMID: 15940674
