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Recombinant Human PTHLH Protein, N-His (PX-P5902)

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概述
货号PX-P5902
品牌ProteoGenix
描述
Recombinant Human PTHLH Protein, N-His (PX-P5902) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
  • High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
  • E. coli Expression — Optimized for functional studies.
表达系统E. coli
Accession号P12272
蛋白长度Ala37-Arg175
应用ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属Homo sapiens (Human)
性质Recombinant
内毒素水平Please contact with the lab for this information.
纯度>90% as determined by SDS-PAGE.
预测分子量18.05 kDa
状态Lyophilized
保存溶液 Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名Parathyroid hormone-like protein, PTHrP, PTH-rP, Parathyroid hormone-related protein, PTHrP[107-139], PLP, PTHRP, PTHLH
背景

Parathyroid hormone-related protein (PTHLH) is a ~20 kDa protein. Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs.

1. Fiaschi-Taesch, NM. et al. (2003) Endocrinology 144, 407-11. PMID: 12538599
2. Kobayashi, K. et al. (2022) Molecular cell 82, 3468-3483.e5. PMID: 35932760
3. Suva, LJ. et al. (1987) Science (New York, N.Y.) 237, 893-6. PMID: 3616618
4. Pioszak, AA. et al. (2009) The Journal of biological chemistry 284, 28382-28391. PMID: 19674967
5. Mula, RV. et al. (2010) Cancer letters 298, 119-27. PMID: 20637541
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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