Recombinant Human PTGER3 Protein, N-His (PX-P5900)
概述
图片
参考文献
概述
货号
PX-P5900
品牌
ProteoGenix
描述
Recombinant Human PTGER3 Protein, N-His (PX-P5900) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
E. coli Expression — Optimized for functional studies.
表达系统
E. coli
Accession号
P43115
蛋白长度
Asn217-Gln359
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
18.38 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Prostaglandin E2 receptor EP3 subtype (PTGER3) is a ~43 kDa protein. Receptor for prostaglandin E2 (PGE2). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration.
1. Schmid, A. et al. (1995) European journal of biochemistry 228, 23-30. PMID: 7883006
2. An, S. et al. (1994) Biochemistry 33, 14496-502. PMID: 7981210
3. Yang, J. et al. (1994) Biochemical and biophysical research communications 198, 999-1006. PMID: 8117308
4. Kunapuli, SP. et al. (1994) The Biochemical journal 298 ( Pt 2), 263-7. PMID: 8135729
5. Adam, M. et al. (1994) FEBS letters 338, 170-4. PMID: 8307176
