Recombinant Human LRRK2 Protein, N-His (PX-P5822)

概述
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参考文献

概述

货号	PX-P5822
品牌	ProteoGenix
描述	Recombinant Human LRRK2 Protein, N-His (PX-P5822) expressed in E. coli, Purity: >90% as determined by SDS-PAGE.. Highlights High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy. E. coli Expression — Optimized for functional studies.
表达系统	E. coli
Accession号	Q5S007
蛋白长度	Phe1479-Pro1729
应用	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属	Homo sapiens (Human)
性质	Recombinant
内毒素水平	Please contact with the lab for this information.
纯度	>90% as determined by SDS-PAGE.
预测分子量	31.84 kDa
状态	Lyophilized
保存溶液	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	Dardarin, Leucine-rich repeat serine/threonine-protein kinase 2, PARK8, LRRK2
背景	Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2/Dardarin) is a ~286 kDa protein. Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking. Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation. Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43. Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A. Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A. 1. MacLeod, D. et al. (2006) Neuron 52, 587-93. PMID: 17114044 2. Zach, S. et al. (2010) PloS one 5, e13191. PMID: 20949042 3. Angeles, DC. et al. (2011) Human mutation 32, 1390-7. PMID: 21850687 4. Gómez-Suaga, P. et al. (2012) Human molecular genetics 21, 511-25. PMID: 22012985 5. MacLeod, DA. et al. (2013) Neuron 77, 425-39. PMID: 23395371 6. Piccoli, G. et al. (2014) Molecular and cellular biology 34, 2147-61. PMID: 24687852 7. Cho, HJ. et al. (2014) The EMBO journal 33, 2314-31. PMID: 25201882 8. Guerreiro, PS. et al. (2016) Molecular neurobiology 53, 3124-3135. PMID: 26014385 9. Steger, M. et al. (2016) eLife 5. PMID: 26824392 10. Yan, R. et al. (2017) Protein & cell 8, 55-66. PMID: 27830463
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Recombinant Human LRRK2 Protein, N-His (PX-P5822)

概述

图片

参考文献

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重组蛋白

抗体

试剂盒

实验相关试剂

Recombinant Human LRRK2 Protein, N-His (PX-P5822)

概述

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参考文献

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