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Human MOV10 Recombinant Protein (N-His) (HC181012)

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  • 50ug
  • 100ug
  • 1mg
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概述
货号HC181012
品牌abinScience
描述
Recombinant Human MOV10 Protein, N-His (HC181012) expressed in E. coli, spanning Glu498-Arg733. Purity: >90% by SDS-PAGE.
Highlights
  • ●His-Tagged — N-terminal 6×His tag for IMAC purification.
  • ●E. coli Expression — High-yield, cost-effective production.
  • ●High Purity — >90% purity verified by SDS-PAGE.
表达系统E. coli
Accession号Q9HCE1
蛋白长度Glu498-Arg733
应用ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属Homo sapiens (Human)
性质Recombinant
内毒素水平Please contact with the lab for this information.
纯度>90% as determined by SDS-PAGE.
预测分子量28.50 kDa
状态Lyophilized
保存溶液 Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名Armitage homolog, EC:3.6.4.13, Helicase MOV-10, KIAA1631, MOV10, Moloney leukemia virus 10 protein
背景

Helicase MOV-10 is a ~113 kDa protein. 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway.

1. Goodier, JL. et al. (2012) PLoS genetics 8, e1002941. PMID: 23093941
2. Cuevas, RA. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3877-86. PMID: 27016603
3. Balinsky, CA. et al. (2017) Journal of virology 91. PMID: 27974568
4. Yang, X. et al. (2022) PLoS pathogens 18, e1010301. PMID: 35157734
5. Wang, X. et al. (2010) The Journal of biological chemistry 285, 14346-55. PMID: 20215113
6. Chen, C. et al. (2017) Retrovirology 14, 56. PMID: 29258557
7. Liu, T. et al. (2019) The Journal of biological chemistry 294, 19804-19813. PMID: 31722967
8. Gregersen, LH. et al. (2014) Molecular cell 54, 573-85. PMID: 24726324
10. Chendrimada, TP. et al. (2007) Nature 447, 823-8. PMID: 17507929
NoteFor research use only
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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