

| 货号 | HC181012 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Human MOV10 Protein, N-His (HC181012) expressed in E. coli, spanning Glu498-Arg733. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | E. coli |
| Accession号 | Q9HCE1 |
| 蛋白长度 | Glu498-Arg733 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 28.50 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | Armitage homolog, EC:3.6.4.13, Helicase MOV-10, KIAA1631, MOV10, Moloney leukemia virus 10 protein |
| 背景 | Helicase MOV-10 is a ~113 kDa protein. 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway. 1. Goodier, JL. et al. (2012) PLoS genetics 8, e1002941. PMID: 23093941 2. Cuevas, RA. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3877-86. PMID: 27016603 3. Balinsky, CA. et al. (2017) Journal of virology 91. PMID: 27974568 4. Yang, X. et al. (2022) PLoS pathogens 18, e1010301. PMID: 35157734 5. Wang, X. et al. (2010) The Journal of biological chemistry 285, 14346-55. PMID: 20215113 6. Chen, C. et al. (2017) Retrovirology 14, 56. PMID: 29258557 7. Liu, T. et al. (2019) The Journal of biological chemistry 294, 19804-19813. PMID: 31722967 8. Gregersen, LH. et al. (2014) Molecular cell 54, 573-85. PMID: 24726324 10. Chendrimada, TP. et al. (2007) Nature 447, 823-8. PMID: 17507929 |
| Note | For research use only |

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