ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
50.40 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
LTBP-1, LTBP1, Latent-transforming growth factor beta-binding protein 1, TGF-beta1-BP-1, Transforming growth factor beta-1-binding protein 1
背景
Latent-transforming growth factor beta-binding protein 1 is a ~186 kDa protein. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
1. Miyazono, K. et al. (1991) The EMBO journal 10, 1091-101. PMID: 2022183
2. Saharinen, J. et al. (1996) The EMBO journal 15, 245-53. PMID: 8617200
3. Gleizes, PE. et al. (1996) The Journal of biological chemistry 271, 29891-6. PMID: 8939931
4. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403
5. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742
