ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
55.08 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
KIAA0156, SART-3, SART3, Spliceosome associated factor 3, U4/U6 recycling protein, Squamous cell carcinoma antigen recognized by T-cells 3, TIP110, Tat-interacting protein of 110 kDa, Tip110, p110 nuclear RNA-binding protein
背景
Spliceosome associated factor 3, U4/U6 recycling protein is a ~109 kDa protein. U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15.
1. Bell, M. et al. (2002) The EMBO journal 21, 2724-35. PMID: 12032085
2. Damianov, A. et al. (2004) Molecular and cellular biology 24, 1700-8. PMID: 14749385
3. Song, EJ. et al. (2010) Genes & development 24, 1434-47. PMID: 20595234
4. Long, L. et al. (2014) The Journal of biological chemistry 289, 8916-30. PMID: 24526689
