ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
38.46 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
5-hydroxytryptamine receptor 1F is a ~41 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Receptor for lasmiditan, a drug for the treatment of acute migraine. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity.
1. Klein, MT. et al. (2011) The Journal of pharmacology and experimental therapeutics 337, 860-7. PMID: 21422162
2. Huang, S. et al. (2021) Cell research 31, 1036-1038. PMID: 34239069
3. Adham, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 408-12. PMID: 8380639
4. Lovenberg, TW. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2184-8. PMID: 8384716
5. Tan, Y. et al. (2022) Cell discovery 8, 50. PMID: 35610220
