Human LAPTM4B Recombinant Protein (N-GST & C-His) (HC812012)

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概述

货号	HC812012
品牌	abinScience
描述	Recombinant Human LAPTM4B Protein, N-GST & C-His (HC812012) expressed in E. coli, spanning Thr2-Thr116. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
表达系统	E. coli
Accession号	Q86VI4
蛋白长度	Thr2-Thr116
应用	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属	Homo sapiens (Human)
性质	Recombinant
内毒素水平	Please contact with the lab for this information.
纯度	>90% as determined by SDS-PAGE.
预测分子量	40.65 kDa
状态	Lyophilized
保存溶液	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	LAPTM4B, Lysosomal-associated transmembrane protein 4B, Lysosome-associated transmembrane protein 4-beta
背景	Lysosomal-associated transmembrane protein 4B is a ~35 kDa protein. Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. 1. Vergarajauregui, S. et al. (2011) Journal of cell science 124, 459-68. PMID: 21224396 2. Tan, X. et al. (2015) The EMBO journal 34, 475-90. PMID: 25588945 3. Milkereit, R. et al. (2015) Nature communications 6, 7250. PMID: 25998567 4. Huygens, C. et al. (2015) The Journal of biological chemistry 290, 20105-16. PMID: 26126825 5. Blom, T. et al. (2015) Nature chemical biology 11, 799-806. PMID: 26280656
Note	For research use only

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参考文献

产品说明书

Human LAPTM4B Recombinant Protein (N-GST & C-His).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

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Human LAPTM4B Recombinant Protein (N-GST & C-His) (HC812012)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Human LAPTM4B Recombinant Protein (N-GST & C-His) (HC812012)

概述

图片

参考文献

产品说明书

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