ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
14.09 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
OATP-H, OATP-M1, OATP4C1, OATPX, Organic anion transporter M1, Organic anion transporting polypeptide 4C1, SLC21A20, SLCO4C1, Solute carrier family 21 member 20, Solute carrier organic anion transporter family member 4C1
背景
Solute carrier organic anion transporter family member 4C1 is a ~78 kDa protein. Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney. Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate. Transport is independent of sodium, chloride ion, and ATP. Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter. The driving force for this transport activity is currently not known.
1. Mikkaichi, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 3569-74. PMID: 14993604
2. Leuthold, S. et al. (2009) American journal of physiology. Cell physiology 296, C570-82. PMID: 19129463
3. Yamaguchi, H. et al. (2010) Drug metabolism and pharmacokinetics 25, 314-7. PMID: 20610891
4. Taghikhani, E. et al. (2019) PloS one 14, e0213747. PMID: 30865704
5. Taghikhani, E. et al. (2020) Amino acids 52, 975-985. PMID: 32642843
