

| 货号 | HC816012 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Human SACM1L Protein, N-His (HC816012) expressed in E. coli, spanning Gly192-Thr466. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | E. coli |
| Accession号 | Q9NTJ5 |
| 蛋白长度 | Gly192-Thr466 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 33.67 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | EC:3.1.3.64, KIAA0851, Phosphatidylinositol-3-phosphatase SAC1, Phosphatidylinositol-4-phosphate phosphatase, SAC1, SACM1L, Suppressor of actin mutations 1-like protein |
| 背景 | Phosphatidylinositol-3-phosphatase SAC1 is a ~66 kDa protein. Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration. PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3. 1. Mesmin, B. et al. (2013) Cell 155, 830-43. PMID: 24209621 2. Dickson, EJ. et al. (2016) The Journal of cell biology 213, 33-48. PMID: 27044890 3. Zewe, JP. et al. (2018) eLife 7. PMID: 29461204 4. Venditti, R. et al. (2019) The Journal of cell biology 218, 783-797. PMID: 30659099 |
| Note | For research use only |

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