Human PHF1 Recombinant Protein (N-His) (HC900012)

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1mg

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概述

货号	HC900012
品牌	abinScience
描述	Recombinant Human PHF1 Protein, N-His (HC900012) expressed in E. coli, spanning Leu31-Arg334. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
表达系统	E. coli
Accession号	O43189
蛋白长度	Leu31-Arg334
应用	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属	Homo sapiens (Human)
性质	Recombinant
内毒素水平	Please contact with the lab for this information.
纯度	>90% as determined by SDS-PAGE.
预测分子量	36.90 kDa
状态	Lyophilized
保存溶液	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	PCL1, PHD finger protein 1, PHF1, Polycomb-like protein 1, Protein PHF1, hPCl1, hPHF1
背景	PHD finger protein 1 is a ~62 kDa protein. Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci. According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. 1. Sarma, K. et al. (2008) Molecular and cellular biology 28, 2718-31. PMID: 18285464 2. Cai, L. et al. (2013) Molecular cell 49, 571-82. PMID: 23273982 3. Musselman, CA. et al. (2012) Nature structural & molecular biology 19, 1266-72. PMID: 23142980
Note	For research use only

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参考文献

产品说明书

Human PHF1 Recombinant Protein (N-His).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

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Human PHF1 Recombinant Protein (N-His) (HC900012)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Human PHF1 Recombinant Protein (N-His) (HC900012)

概述

图片

参考文献

产品说明书

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