

| 货号 | HD221012 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Human LPIN1 Protein, N-His (HD221012) expressed in E. coli, spanning Asn621-Pro851. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | E. coli |
| Accession号 | Q14693 |
| 蛋白长度 | Asn621-Pro851 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 28.53 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | EC:3.1.3.4, KIAA0188, LPIN1, Lipin-1, Phosphatidate phosphatase LPIN1 |
| 背景 | Phosphatidate phosphatase LPIN1 is a ~98 kDa protein. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels. Is involved in adipocyte differentiation. Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. 1. Han, GS. et al. (2010) The Journal of biological chemistry 285, 14628-38. PMID: 20231281 2. Eaton, JM. et al. (2013) The Journal of biological chemistry 288, 9933-9945. PMID: 23426360 3. Li, TY. et al. (2018) Nature communications 9, 1916. PMID: 29765047 4. MacVicar, T. et al. (2019) Nature 575, 361-365. PMID: 31695197 |
| Note | For research use only |

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