ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
43.62 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
EC:1.14.11.-, JHDM2C, JMJD1C, Jumonji domain-containing protein 1C, KIAA1380, Probable JmjC domain-containing histone demethylation protein 2C, TR-interacting protein 8, TRIP-8, TRIP8, Thyroid receptor-interacting protein 8
背景
Jumonji domain-containing protein 1C is a ~284 kDa protein. Demethylates lysine in proteins, such as STAT3 or MDC1. Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination essential for double-strand break (DSB) repair. Demethylation of STAT3 at 'Lys-140' facilitates its interactions with the phosphatase PTPN6 and restrains STAT3 activation. It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD1/KDM3 proteins do. Nevertheless, JMJD1C may act as a context-specific histone demethylase.
1. Watanabe, S. et al. (2013) Nature structural & molecular biology 20, 1425-33. PMID: 24240613
2. Brauchle, M. et al. (2013) PloS one 8, e60549. PMID: 23593242
