Human QRICH1 Recombinant Protein (N-His) (HD267012)

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1mg

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概述

货号	HD267012
品牌	abinScience
描述	Recombinant Human QRICH1 Protein, N-His (HD267012) expressed in E. coli, spanning Leu473-His776. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
表达系统	E. coli
Accession号	Q2TAL8
蛋白长度	Leu473-His776
应用	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属	Homo sapiens (Human)
性质	Recombinant
内毒素水平	Please contact with the lab for this information.
纯度	>90% as determined by SDS-PAGE.
预测分子量	37.59 kDa
状态	Lyophilized
保存溶液	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	Glutamine-rich protein 1, QRICH1, Transcriptional regulator QRICH1
背景	Transcriptional regulator QRICH1 is a ~86 kDa protein. Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. 1. You, K. et al. (2021) Science (New York, N.Y.) 371. PMID: 33384352 2. Zhang, L. et al. (2025) Molecular medicine (Cambridge, Mass.) 31, 183. PMID: 40355839 3. Bianchi, D. et al. (2025) Science (New York, N.Y.) 389, eadv2861. PMID: 40608935 4. Lui, JC. et al. (2019) Clinical genetics 95, 160-164. PMID: 30281152
Note	For research use only

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参考文献

产品说明书

Human QRICH1 Recombinant Protein (N-His).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

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Human QRICH1 Recombinant Protein (N-His) (HD267012)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Human QRICH1 Recombinant Protein (N-His) (HD267012)

概述

图片

参考文献

产品说明书

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