

| 货号 | HD352012 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Human PAQR3 Protein, N-His-KSI (HD352012) expressed in E. coli, spanning His2-Trp74. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | E. coli |
| Accession号 | Q6TCH7 |
| 蛋白长度 | His2-Trp74 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 24.37 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | PAQR3, Progestin and adipoQ receptor family member 3, Progestin and adipoQ receptor family member III, RKTG, Raf kinase trapping to Golgi |
| 背景 | Progestin and adipoQ receptor family member 3 is a ~36 kDa protein. Golgi-scaffold protein which modulates its interactors acitivies by anchoring them to the Golgi apparatus. Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus. Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis. Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation. 1. Luo, X. et al. (2008) The Biochemical journal 414, 399-406. PMID: 18547165 2. Xu, D. et al. (2015) Nature communications 6, 8100. PMID: 26311497 |
| Note | For research use only |

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