

| 货号 | HF729021 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Human MPIG6B/G6b Protein, C-Fc (HF729021) expressed in Mammalian Cells, spanning Met1-Gln142. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | Mammalian cells |
| Accession号 | O95866 |
| 蛋白长度 | Met1-Gln142 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 41.69 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | C6orf25, G6B, G6B-B, MPIG6B, Megakaryocyte and platelet inhibitory receptor G6b, Protein G6b |
| 背景 | Megakaryocyte and platelet inhibitory receptor G6b is a ~26 kDa protein. Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner. 1. Gevaert, K. et al. (2003) Nature biotechnology 21, 566-9. PMID: 12665801 2. Newland, SA. et al. (2007) Blood 109, 4806-9. PMID: 17311996 3. Melhem, M. et al. (2017) European journal of haematology 98, 218-227. PMID: 27743390 |
| Note | For research use only |

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