ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Mus musculus (Mouse)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
31.30 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
CaT-L, CaT-like, CaT1, Calcium transport protein 1, ECAC2, ECaC2, Epithelial calcium channel 2, TRPV6, Transient receptor potential cation channel subfamily V member 6, TrpV6
背景
Transient receptor potential cation channel subfamily V member 6 is a ~87 kDa protein. Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner.
1. Hoenderop, JG. et al. (2003) The EMBO journal 22, 776-85. PMID: 12574114
2. Voets, T. et al. (2003) The Journal of general physiology 121, 245-60. PMID: 12601087
3. Hirnet, D. et al. (2003) Cell calcium 33, 509-18. PMID: 12765696
4. Voets, T. et al. (2004) The Journal of biological chemistry 279, 15223-30. PMID: 14736889
5. Lambers, TT. et al. (2004) The Journal of biological chemistry 279, 28855-61. PMID: 15123711
6. Bianco, SD. et al. (2007) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 22, 274-85. PMID: 17129178
7. Woudenberg-Vrenken, TE. et al. (2012) American journal of physiology. Gastrointestinal and liver physiology 303, G879-85. PMID: 22878123
