Human CD203c/ENPP3 Recombinant Protein (C-Strep) (HT018011)
概述
图片
参考文献
产品说明书
概述
货号
HT018011
品牌
abinScience
描述
Recombinant Human CD203c/ENPP3 Protein, C-Strep (HT018011) expressed in Mammalian Cells, spanning Leu48-Ile875. Purity: >90% by SDS-PAGE.
Highlights
●Mammalian Expression — Proper folding and native glycosylation.
●High Purity — >90% purity verified by SDS-PAGE.
表达系统
Mammalian cells
Accession号
O14638
蛋白长度
Leu48-Ile875
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
98.18 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
Alkaline phosphodiesterase I, CD203c, Dinucleoside polyphosphatase, E-NPP 3, EC:3.1.4.1, EC:3.6.1.-, EC:3.6.1.9, ENPP3, Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, NPP3, NPPase, Nucleotide diphosphatase, Nucleotide pyrophosphatase, PD-Ibeta, PDNP3, Phosphodiesterase I beta, Phosphodiesterase I/nucleotide pyrophosphatase 3
背景
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is a ~100 kDa protein. Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response. 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells.
1. Gorelik, A. et al. (2018) The FEBS journal 285, 2481-2494. PMID: 29717535
2. Jin-Hua, P. et al. (1997) Genomics 45, 412-5. PMID: 9344668
3. Mardjuki, R. et al. (2024) Cell reports 43, 114209. PMID: 38749434
4. Vollmayer, P. et al. (2003) European journal of biochemistry 270, 2971-8. PMID: 12846830
