ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
16.38 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
Alpha-SGT, SGT, SGT1, SGTA, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, UBP, Vpu-binding protein
背景
Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a ~34 kDa protein. Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states.
1. Shao, S. et al. (2017) Science (New York, N.Y.) 355, 298-302. PMID: 28104892
2. Mock, JY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 106-11. PMID: 25535373
3. Leznicki, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 19214-9. PMID: 23129660
4. Wunderley, L. et al. (2014) Journal of cell science 127, 4728-39. PMID: 25179605
