ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
17.37 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
HBeAg-binding protein 3, KIAA0869, KIBRA, Kidney and brain protein, Protein KIBRA, WW domain-containing protein 1, WWC1
背景
Protein KIBRA is a ~125 kDa protein. Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade.
1. Wennmann, DO. et al. (2014) Molecular biology and evolution 31, 1710-23. PMID: 24682284
2. Yu, J. et al. (2010) Developmental cell 18, 288-99. PMID: 20159598
3. Rayala, SK. et al. (2006) The Journal of biological chemistry 281, 19092-9. PMID: 16684779
4. Hilton, HN. et al. (2008) Biochimica et biophysica acta 1783, 383-93. PMID: 18190796
5. Duning, K. et al. (2008) Journal of the American Society of Nephrology : JASN 19, 1891-903. PMID: 18596123
6. Johannsen, S. et al. (2008) Neuroscience 155, 1165-73. PMID: 18672031
