Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc) (MV480011)
概述
图片
参考文献
产品说明书
概述
货号
MV480011
品牌
abinScience
描述
Recombinant Mouse CD270/TNFRSF14 Protein, C-Fc (MV480011) expressed in Mammalian Cells, spanning Met1-Gln206. Purity: >90% by SDS-PAGE.
Highlights
●Fc Fusion — Enhanced stability with Protein A/G purification compatibility.
●Mammalian Expression — Proper folding and native glycosylation.
●High Purity — >90% purity verified by SDS-PAGE.
表达系统
Mammalian cells
Accession号
Q80WM9
蛋白长度
Met1-Gln206
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Mus musculus (Mouse)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
48.94 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
CD270, HVEA, HVEM, Herpes virus entry mediator A, Herpesvirus entry mediator A, HveA, TNFRSF14, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2
背景
Tumor necrosis factor receptor superfamily member 14 is a ~30 kDa protein. Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response.
1. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044
2. Tu, TC. et al. (2015) The Journal of experimental medicine 212, 415-29. PMID: 25711213
4. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026
Note
For research use only
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Bioactivity
Immobilized HV375011 Human CD272/BTLA Recombinant Protein (C-His) at 2 μg/mL(100 μL/well) can bind MV480011 Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc), the EC 50 is 13.1 ng/mL.
Bioactivity
Immobilized HV375021 Human BTLA Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind MV480011 Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc), the EC 50 is 251 ng/mL.
