

| 货号 | MW406011 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Mouse CD239/BCAM Protein, C-His (MW406011) expressed in Mammalian Cells, spanning Glu26-Ala541. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | Mammalian cells |
| Accession号 | Q9R069 |
| 蛋白长度 | Glu26-Ala541 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Mus musculus (Mouse) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 59.76 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | Auberger B antigen, B-CAM cell surface glycoprotein, BCAM, Basal cell adhesion molecule, CD239, F8/G253 antigen, LU, Lutheran antigen, Lutheran blood group glycoprotein, MSK19 |
| 背景 | Basal cell adhesion molecule is a ~67 kDa protein. Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR. |
| Note | For research use only |

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