

| 货号 | MW575011 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Mouse DSG3 Protein, C-His (MW575011) expressed in Mammalian Cells, spanning Met1-Thr607. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | Mammalian cells |
| Accession号 | O35902 |
| 蛋白长度 | Met1-Thr607 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Mus musculus (Mouse) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 68.51 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | 130 kDa pemphigus vulgaris antigen, CDHF6, Cadherin family member 6, DSG3, Desmoglein-3, PVA |
| 背景 | Desmoglein-3 is a ~107 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes. Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle. Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells. May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3. 1. Koch, PJ. et al. (1997) The Journal of cell biology 137, 1091-102. PMID: 9166409 2. Koch, PJ. et al. (1998) Journal of cell science 111 ( Pt 17), 2529-37. PMID: 9701552 3. Rötzer, V. et al. (2016) The Journal of investigative dermatology 136, 301-10. PMID: 26763450 |
| Note | For research use only |

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