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Human SAMTOR Recombinant Protein (N-His) (HD581012)

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概述
货号HD581012
品牌abinScience
描述
Recombinant Human SAMTOR Protein, N-His (HD581012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
  • ●E. coli Expression — High-yield, cost-effective production.
  • ●High Purity — >90% as determined by SDS-PAGE.
表达系统E. coli
Accession号Q1RMZ1
蛋白长度Glu34-Asn354
应用ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属Homo sapiens (Human)
性质Recombinant
内毒素水平Please contact with the lab for this information.
纯度>90% as determined by SDS-PAGE.
状态Lyophilized
保存溶液 Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名BMT2, C7orf60, EC:2.1.1.-, Probable methyltransferase BMT2 homolog, S-adenosylmethionine sensor upstream of mTORC1, SAMTOR
背景

S-adenosylmethionine sensor upstream of mTORC1 is a ~46 kDa protein. S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).

1. Gu, X. et al. (2017) Science (New York, N.Y.) 358, 813-818. PMID: 29123071
2. Tang, X. et al. (2022) Science advances 8, eabn3868. PMID: 35776786
NoteFor research use only
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公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
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质量
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体积
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公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
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V₁ (起始体积)
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工作液
C₂ (终浓度)
×
V₂ (终体积)

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