ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Canis lupus familiaris (Dog) (Canis familiaris)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
40.42 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
CD107 antigen-like family member A, CD107a, LAMP-1, LAMP1, Lysosome-associated membrane glycoprotein 1, Lysosome-associated membrane protein 1
背景
Lysosome-associated membrane glycoprotein 1 (CD107a/LAMP1) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content.
1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818
2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921
3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890
4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195
5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349
