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C. botulinum botE Recombinant Protein (N-His) (JN161022)

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概述

货号	JN161022
品牌	abinScience
描述	Recombinant C. botulinum botE Protein, N-His (JN161022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
表达系统	E. coli
Accession号	Q00496
蛋白长度	Ser850-Lys1251
应用	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属	Clostridium botulinum
性质	Recombinant
内毒素水平	Please contact with the lab for this information.
纯度	>90% as determined by SDS-PAGE.
状态	Lyophilized
保存溶液	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	BoNT/E, Bontoxilysin-E, Botulinum neurotoxin E heavy chain, Botulinum neurotoxin E light chain, Botulinum neurotoxin type E, EC:3.4.24.69, HC, LC, botE
背景	Botulinum neurotoxin type E is a ~143 kDa protein. Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin E which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. 1. Fu, Z. et al. (2009) Biochemistry 48, 5631-41. PMID: 19476346 2. Rummel, A. et al. (2009) Journal of neurochemistry 110, 1942-54. PMID: 19650874 3. Sun, S. et al. (2012) Biochemistry 51, 5655-62. PMID: 22720883 4. Dong, M. et al. (2008) Molecular biology of the cell 19, 5226-37. PMID: 18815274
Note	For research use only

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参考文献

产品说明书

C. botulinum botE Recombinant Protein (N-His).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

=

浓度

×

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

×

V₁ (起始体积)

=

工作液

C₂ (终浓度)

×

V₂ (终体积)

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C. botulinum botE Recombinant Protein (N-His)

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