ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
26.29 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Mucolipin-1 is a ~65 kDa protein. Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion.
1. Bassi, MT. et al. (2000) American journal of human genetics 67, 1110-20. PMID: 11013137
2. LaPlante, JM. et al. (2002) FEBS letters 532, 183-7. PMID: 12459486
3. Raychowdhury, MK. et al. (2004) Human molecular genetics 13, 617-27. PMID: 14749347
4. LaPlante, JM. et al. (2004) Biochemical and biophysical research communications 322, 1384-91. PMID: 15336987
