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Human DDX39A Recombinant Protein (N-His) (HD747012)

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  • 50ug
  • 100ug
  • 1mg
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概述
货号HD747012
品牌abinScience
描述
Recombinant Human DDX39A Protein, N-His (HD747012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
  • ●E. coli Expression — High-yield, cost-effective production.
  • ●High Purity — >90% as determined by SDS-PAGE.
表达系统E. coli
Accession号O00148
蛋白长度Arg47-Arg427
应用ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属Homo sapiens (Human)
性质Recombinant
内毒素水平Please contact with the lab for this information.
纯度>90% as determined by SDS-PAGE.
预测分子量46.32 kDa
状态Lyophilized
保存溶液 Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名ATP-dependent RNA helicase DDX39A, DDX39, DDX39A, DEAD box protein 39, EC:3.6.4.13, Nuclear RNA helicase URH49
背景

ATP-dependent RNA helicase DDX39A is a ~49 kDa protein. Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA.

1. Saleem, I. et al. (2021) Molecular and cellular biology 41, e0010321. PMID: 33941617
2. Banerjee, S. et al. (2024) Nucleic acids research 52, 8534-8551. PMID: 38801080
3. Taniguchi, I. et al. (2024) Nucleic acids research 52, 10668-10682. PMID: 39011894
4. Shi, P. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 205, 168-180. PMID: 32393512
5. Tapescu, I. et al. (2023) Molecular cell 83, 4174-4189.e7. PMID: 37949067
NoteFor research use only
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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