ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
14.65 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
CREB-3, CREB3, Cyclic AMP-responsive element-binding protein 3, LZIP, Leucine zipper protein, Luman, N-terminal Luman, Processed cyclic AMP-responsive element-binding protein 3, Transcription factor LZIP-alpha, Transcriptionally active form, cAMP-responsive element-binding protein 3
背景
Cyclic AMP-responsive element-binding protein 3 is a ~41 kDa protein. Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription. Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death. Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Associates with chromatin to the HERPUD1 promoter.
1. Luciano, RL. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 10757-62. PMID: 10984507
2. DenBoer, LM. et al. (2005) Biochemical and biophysical research communications 331, 113-9. PMID: 15845366
3. Liang, G. et al. (2006) Molecular and cellular biology 26, 7999-8010. PMID: 16940180
4. Kang, H. et al. (2009) Molecular endocrinology (Baltimore, Md.) 23, 1746-57. PMID: 19779205
5. Lu, R. et al. (1997) Molecular and cellular biology 17, 5117-26. PMID: 9271389
6. Ko, J. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 890-2. PMID: 15001559
7. Jang, SW. et al. (2007) The Journal of biological chemistry 282, 11092-100. PMID: 17296613
